Preheat oven to 350°.
Line cupcake tins with liners and place a Samoa cookie in the bottom of each liner.
In the bowl of your stand mixer fitter with the paddle attachment, combine the flour, sugar, baking powder, baking soda and salt and stir together.
Pour in the buttermilk and gently stir until just combined.
Add in the eggs, vanilla and vegetable oil and mix until the batter comes together, but do not overmix.
Fill the cupcake liners about 2/3 of the way full. Bake for 15-18 minutes, or until a toothpick comes out clean.
Allow the cupcake to cool in the tins for a few minutes before you remove them and then transfer to a wire rack to fully cool.